SnapShot: Mitochondrial Quality Control

SnapShot: Mitochondrial Quality Control

SnapShot: Mitochondrial Dynamics

SnapShot: Mitochondrial Architecture

Mammals C. elegans 1 TM domain; C-term in IMS and N-term in the matrix. IBM & CJ; self-oligomerizes, binds MICOS/MINOS/MitOS components and Sam50, Tob38, Ugo1, Fzo1. Yeast are viable but exhibit altered mtDNA inheritance and decreased respiratory growth. Mammals and worms exhibit increased ROS production and apoptosis. Loss of CJ, altered cristae structure, accumulation of cristae stacks and cr...

Mitochondrial dynamics and mitochondrial quality control

Mitochondria are cellular energy powerhouses that play important roles in maintaining cell survival, cell death and cellular metabolic homeostasis. Timely removal of damaged mitochondria via autophagy (mitophagy) is thus critical for cellular homeostasis and function. Mitochondria are reticular organelles that have high plasticity for their dynamic structures and constantly undergo fission and ...

SnapShot: Import and Sortingof Mitochondrial Proteins